In the first month of 2021, as an uplifting example of excellence in research, I’d like to share a link (see below*) to the December 2020 Nobel Lectures in Chemistry concerning work in the field of CRISPR and gene editing.

See what doing science is like – and how scientists work together.
Feel the joy of discovery – and the clarity of communication.

Dip in or delve deeper to learn about the fascinating science of gene editing.
Enjoy lectures by 2 highly successful scientists, recipients of the Nobel Prize 2020.

The presentations describe fundamental biology and show how research in bacteria and viruses can be valuable for developments in biotechnology. Challenges and opportunities are discussed. There are pointers to where such research is heading and its applications in research, public health, agriculture, and biomedicine. The lectures also touch on its potential use in applications for covid detection and screening, and indeed for future pandemic preparedness.

Hear 2 leaders in their field praising the enthusiasm and commitment of young scientists. It is indeed an exciting time for scientific research, and CRISPR methodology is ‘a powerful tool for young scientists’.

International collaboration is important. The mobility of researchers enables them to work in different labs and encourages the circulation of ideas.

In view of the opportunities and where some of this research is heading I think people should be prepared for wider consultations. It is important to increase the general understanding about this technology.

by Dr Julie Charlesworth 20/1/21

*
Click here for the link to the 2020 Nobel Lectures in Chemistry
Thanks to ‘The Nobel Prize’and the scientists involved.

……

[Here is a link to a piece I wrote previously on a similar topic, frontier research in synthetic biology]

Wishing everyone a Happy New Year!

A huge thank you to those who have supported me over the years.

There is much to reflect on and much to look forward to. However, for now, today, 2 thoughts for 2021:

‘It is better to light a candle than to curse the darkness’

&

‘When the roots are deep there is no reason to fear the wind’.

So, it’s a Happy New Year from myself and A Tree of Life Sciences®. Always serious about Life, Science and of course Life Sciences! & on occasions playful with an extra twinkle ⭐️.

Here’s to successful science, hugs and happiness for all 🌎 🧬 ❤️.

by Dr Julie Charlesworth 1/1/21

Take care, stay safe, save Santa 🎅😊😉.
He really wants to come and spread a little magic.

(A card I made earlier – in a playful moment)

Wishing everyone a Merry Christmas, Happy Holidays, Peace and Perspective in this run-up period in strange times.

Take care and have some festive fun fellow Earthlings❤️🌎⭐.

by Dr Julie Charlesworth 17/12/20

Here are some moments captured in photos I took during the first autumn of the Covid-19 pandemic. I’d also like to reflect on some thoughts I had in these moments.

Early October, 2020

Keeping things in perspective

There’s so much happening out there in the world, that sometimes, it is important to try to see things in perspective and also to try to get some peace and slumber, for our own sakes and well-being. My photos are of the sun setting in Nice, France, taken just days after raging storms. Here’s to peace and quiet at times and the ‘honey-heavy dew of slumber’ to carry us through the nights.

[P.S as always no filters used – it’s the real thing! Sun setting as it happened, snap shots left to right.]

These photos brought some warmth, colour and perspective. A reminder to take time to pause, sleep and take care. Tomorrow another day begins, and some things may look different again. The simplest things in life give us the most pleasure.

Late October, 2020

Staying positive

I was serving 2 weeks of self-isolation in accordance with current rules. I was at home up North in the UK. Autumn brings warmth with rich tones of foliage in the garden. In the evening they contrast against the chilly grey sky. As nightfall descends the soft suffusion of colours blend into pitch black darkness.

(My photos left to right capture different perspectives of autumn from my home)

The next morning heralds another day. Peeping through the front window blinds, I am drawn by a new perspective. I raise the blinds to behold a glorious golden spectacle of Nature. Life is good and I’ll soon be out and about again.

November, 2020

‘Better to light a candle than to curse the darkness’

But on Bonfire Night, November 5th – here in England – I thought a spark in the dark or rather a sparkler in the darkness was fitting. We probably needed a bit of sparkle on Day 1 Lockdown 2.

(Photos taken Day 1 Lockdown 2 up North here in England)

November is coming to a close now and the end of Lockdown 2 in England (UK) is in sight. Restrictions will continue but will be eased in some respects; these are still uncertain times. December will be a different phase and there already is a sense of optimism with recent scientific and medical developments. Nevertheless, many people are suffering emotionally and in different ways that may not be immediately obvious. The last month of 2020 will be a time for reflection on how we have felt and what we have learned. Autumn will pass and winter approaches.

We are here, we are in this together and we go forward together.
Here’s to keeping things in perspective, staying positive and seeing the light ahead.

by Dr Julie Charlesworth 30/11/20

Open science, and in particular data sharing to improve research, has long been a theme of the EuroScience Open Forum (ESOF). Most recently, a session at ESOF2020 discussed some learning from experience in the current Covid-19 pandemic. A link to the recording of the session ‘Open science in time of pandemics: the experience of the Research Data Alliance WG on COVID-19’ is provided below*.

Starting in March 2020, over a 3-month period several working groups were formed and many people were brought together to address the challenges of data sharing in the pandemic. It was an advantage that the Research Data Alliance (RDA) already existed (since 2013). There was also some collaboration between the RDA and the EOSC group (European Open Science Cloud – an infrastructure currently being developed). It was an intense 3-month period resulting in the release of a document produced to record and share the learning so that others can be more prepared in future. Key steps that were identified include the listing of data that can be trusted and the setting of standards for describing and defining data. An important consideration is that undue influence by any one particular jurisdiction should be avoided because the pandemic is affecting everyone and in many different ways.

The ESOF session included discussion of the kinds of collaboration needed. Cross-disciplinary interaction is very important in a pandemic because of the need to look at many different aspects. International aspects also need to be taken into account. Tools need to be able to quickly find out what is of use in such times of emergency. We may need better systems and infrastructure to handle pandemics in the future. Global problems have the challenges of harmonisation, and this might be facilitated by the development of appropriate frameworks.

The session also aimed to increase awareness of the existence of the document ‘RDA COVID-19 Recommendations and Guidelines on Data Sharing’ (reference below**)

A message for the future: Data sharing is possible and there are ways to do it; progress has been made because of this pandemic.

by Dr Julie Charlesworth 23/11/20

Sources and further reading:

ESOF2020 Press Conference September 2020

*ESOF2020 session ‘Open science in time of pandemics: the experience of the Research Data Alliance WG on COVID-19’

**RDA COVID-19 Working Group. Recommendations and Guidelines
on data sharing. Research Data Alliance. 2020. DOI:
https://doi.org/10.15497/rda00052

It is World Antimicrobial Awareness Week (November 18 – 24, 2020).

The danger of antimicrobial resistance is something we have been aware of for years. However, it often takes a specific event or a simple communication to jolt us as individuals to action. This is a subject I have posted about several times before here.

‘Antimicrobial resistance (AMR) occurs when bacteria, viruses, fungi, and parasites resist the effects of medications, making common infections harder to treat and increasing the risk of disease spread, severe illness and death.’ WHO*

‘The unchecked growth of drug-resistant infections is a silent pandemic with long-term implications for global health’ GARDP*

We are in this together and hopefully we can share the learning from the covid pandemic to address future challenges.

by Dr Julie Charlesworth 18/11/20

*
GARDP (Global Antibiotic R&D Partnership)
WHO (World Health Organization)]

It is great to see professional groups, networks, forums, associations, companies, institutes, agencies and individuals – speaking out or just getting on with it! Many science, medical, health and medcomms communicators and writers are doing the right thing by promoting and supporting high standards and working with transparency, openness, timeliness and integrity. There were already some long-term proponents of such causes and many more are now rising to such challenges which are even more important in these troubled times.

I made a call out some 6 months ago, which was very well-received. The points are still very pertinent…

‘To the professional communicators in science particularly life sciences, clinical research and medicine. Now is the time to get it right. Now is a good time for you – to write. Too right it is because:

Science writers and medical writers can:
· help with results interpretation and provide appropriate language and wording.
· improve the writing quality.
· speed up the processes of trial and regulatory document development.

Science, medical and medcomms communicators can:
· call out the fake, inaccurate and poor reports.
· improve the quality of messages and conclusions in communications.
· facilitate understanding and evidence-based decisions.

And these are just some of the ways…

You know the need is there and you can help. So, tell them!’

I wrote this message and posted it to my networks on LinkedIn and more publicly (early in the pandemic and again more recently).

I am proud to know a lot of good people out there who are doing the right thing.

by Dr Julie Charlesworth 02/11/20

A year ago (before covid-19) I co-authored two papers on population health intervention. I posted about them in this article. They have proved to be very relevant and timely.

.

The current coronavirus issues exemplify this message.

Antibacterial resistance (another subject I have posted about previously) continues to be a major issue where such approaches are very important.

More recently, I hope you have also read the short articles I wrote (and posted here on this website and on LinkedIn) that refer to the value of international collaboration, interdisciplinary approaches and open communication. The articles focus on and link to two recent publications on population health intervention research (PHIR).

I think it is valuable (and also challenging) to be open to a more holistic approach whilst being rigorous and scientifically sound. Future projects may benefit from more partnerships and collaborations.

by Dr Julie Charlesworth

I just wanted to share some moments of reflection, captured in snapshots I have taken over the winter. Here’s to freedom and flexibility; working on what you want and where you want.

The photos are Manchester city centre; an evening shot from a car park in Cheshire just south of Manchester; and some coastal views in Nice, France.

Sometimes it feels good to pause, take a breath and appreciate the different shades of winter in places where we find ourselves. Beyond traditional winter scenes the winter colour palette can be cool and deep, and also diverse.

Take care – the weather is wild and unpredictable at times these days. Here’s to clearer skies and calmer times…

by Dr Julie Charlesworth 12.3.20